The Debenhams store in Witney is scheduled to close on 15 January.
The store in Witney is among the wave of closures planned for this month as part of a rescue plan announced last year that will see 50 of its worst-performing stores close over the next three years.
In April 2019, Debenhams plc - the holding company for Debenhams Retail - entered into Administration. The operating businesses were acquired by a consortium of lenders who embarked on a restructuring plan with 50 stores expected to close over three years.
The first three stores - York, Haverfordwest and Orpington - were shut towards the end of last year, and a further 19 are scheduled for closure this January which is expected to result in 660 job losses.
Debenhams could not confirm how many jobs would be lost in Witney but said it would try to 'redeploy' as many staff as possible.
The company has confirmed that the timing of another 28 stores planned for closures will be based on the outcomes of talks with landlords.
Debenhams will still have over 100 stores across the UK when the closure programme is complete.